Vanderbilt’s Carrie K. Jones and Andrew Tobin from the University of Glasgow have been awarded a notable £5 million ($6.2 million) Wellcome Trust Discovery Award to investigate how inhibiting the M5 muscarinic receptor in the brain may diminish opioid dependency while maintaining pain relief. This pioneering global partnership, backed by the Warren Center for Neuroscience Drug Discovery, seeks to promote novel therapies in the vital worldwide health emergency of opioid use disorder.