The ascending thoracic aortic aneurysm (ATAA) refers to a dilation or weakening in the upper (thoracic) section of the aorta, which is the largest blood vessel in the body responsible for delivering oxygenated blood to other areas. ATAA can pose significant health risks, and outcomes can vary between males and females; however, the elements that affect the progression of ATAA, such as the role of sex hormones, are still not well comprehended.

A new initiative led by Krashn Dwivedi, a postdoctoral scholar at the McKelvey School of Engineering at Washington University in St. Louis, aims to explore the impact of the sex hormone estrogen on the formation of thoracic aortic aneurysms. Furthermore, Dwivedi will create individualized biomarkers for managing ATAA. This research is backed by a $156,640 grant for two years from the American Heart Association.

“It is widely recognized that severe cardiovascular issues, such as aortic aneurysm and its dissection, are life-threatening and present differently in women compared to men,” stated Dwivedi, who is part of the Vascular Mechanics Lab under the direction of Jessica Wagenseil, vice dean for faculty advancement and a professor of mechanical engineering and materials science. “This holds true for conditions like ATAA that lack clear external symptoms. This research will contribute to bridging part of the gap in our knowledge of women’s cardiovascular health.”

For further details, visit the McKelvey Engineering website.

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